Ryan Babbush
Ryan is the director of the Quantum Algorithm & Applications Team at Google. The mandate of this research team is to develop new and more efficient quantum algorithms, discover and analyze new applications of quantum computers, build and open source tools for accelerating quantum algorithms research and compilation, and to design algorithmic experiments to execute on existing and future fault-tolerant quantum devices.
Authored Publications
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Fast electronic structure quantum simulation by spectrum amplification
Guang Hao Low
Robbie King
Dominic Berry
Qiushi Han
Albert Eugene DePrince III
Alec White
Rolando Somma
arXiv:2502.15882 (2025)
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The most advanced techniques using fault-tolerant quantum computers to estimate the ground-state energy of a chemical Hamiltonian involve compression of the Coulomb operator through tensor factorizations, enabling efficient block-encodings of the Hamiltonian. A natural challenge of these methods is the degree to which block-encoding costs can be reduced. We address this challenge through the technique of spectrum amplification, which magnifies the spectrum of the low-energy states of Hamiltonians that can be expressed as sums of squares. Spectrum amplification enables estimating ground-state energies with significantly improved cost scaling in the block encoding normalization factor $\Lambda$ to just $\sqrt{2\Lambda E_{\text{gap}}}$, where $E_{\text{gap}} \ll \Lambda$ is the lowest energy of the sum-of-squares Hamiltonian. To achieve this, we show that sum-of-squares representations of the electronic structure Hamiltonian are efficiently computable by a family of classical simulation techniques that approximate the ground-state energy from below. In order to further optimize, we also develop a novel factorization that provides a trade-off between the two leading Coulomb integral factorization schemes-- namely, double factorization and tensor hypercontraction-- that when combined with spectrum amplification yields a factor of 4 to 195 speedup over the state of the art in ground-state energy estimation for models of Iron-Sulfur complexes and a CO$_{2}$-fixation catalyst.
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Given copies of a quantum state $\rho$, a shadow tomography protocol aims to learn all expectation values from a fixed set of observables, to within a given precision $\epsilon$. We say that a shadow tomography protocol is \textit{triply efficient} if it is sample- and time-efficient, and only employs measurements that entangle a constant number of copies of $\rho$ at a time. The classical shadows protocol based on random single-copy measurements is triply efficient for the set of local Pauli observables. This and other protocols based on random single-copy Clifford measurements can be understood as arising from fractional colorings of a graph $G$ that encodes the commutation structure of the set of observables. Here we describe a framework for two-copy shadow tomography that uses an initial round of Bell measurements to reduce to a fractional coloring problem in an induced subgraph of $G$ with bounded clique number. This coloring problem can be addressed using techniques from graph theory known as \textit{chi-boundedness}. Using this framework we give the first triply efficient shadow tomography scheme for the set of local fermionic observables, which arise in a broad class of interacting fermionic systems in physics and chemistry. We also give a triply efficient scheme for the set of all $n$-qubit Pauli observables. Our protocols for these tasks use two-copy measurements, which is necessary: sample-efficient schemes are provably impossible using only single-copy measurements. Finally, we give a shadow tomography protocol that compresses an $n$-qubit quantum state into a $\poly(n)$-sized classical representation, from which one can extract the expected value of any of the $4^n$ Pauli observables in $\poly(n)$ time, up to a small constant error.
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We introduce sum-of-squares spectral amplification (SOSSA), a framework for improving quantum simulation algorithms relevant to low-energy problems. SOSSA first represents the Hamiltonian as a sum-of-squares and then applies spectral amplification to amplify the low-energy spectrum. The sum-of-squares representation can be obtained using semidefinite programming. We show that SOSSA can improve the efficiency of traditional methods in several simulation tasks involving low-energy states. Specifically, we provide fast quantum algorithms for energy and phase estimation that improve over the state-of-the-art in both query and gate complexities, complementing recent results on fast time evolution of low-energy states. To further illustrate the power of SOSSA, we apply it to the Sachdev-Ye-Kitaev model, a representative strongly correlated system, where we demonstrate asymptotic speedups by a factor of the square root of the system size. Notably, SOSSA was recently used in [G.H. Low \textit{et al.}, arXiv:2502.15882 (2025)] to achieve state-of-art costs for phase estimation of real-world quantum chemistry systems.
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Quartic Quantum Speedups for Planted Inference Problems
Alexander Schmidhuber
Ryan O'Donnell
Physical Review X, 15 (2025), pp. 021077
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We describe a quantum algorithm for the Planted Noisy kXOR problem (also known as sparse Learning Parity with Noise) that achieves a nearly quartic (4th power) speedup over the best known classical algorithm while also only using logarithmically many qubits. Our work generalizes and simplifies prior work of Hastings, by building on his quantum algorithm for the Tensor Principal Component Analysis (PCA) problem. We achieve our quantum speedup using a general framework based on the Kikuchi Method (recovering the quartic speedup for Tensor PCA), and we anticipate it will yield similar speedups for further planted inference problems. These speedups rely on the fact that planted inference problems naturally instantiate the Guided Sparse Hamiltonian problem. Since the Planted Noisy kXOR problem has been used as a component of certain cryptographic constructions, our work suggests that some of these are susceptible to super-quadratic quantum attacks.
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Rapid Initial-State Preparation for the Quantum Simulation of Strongly Correlated Molecules
Dominic Berry
Yu Tong
Alec White
Tae In Kim
Lin Lin
Seunghoon Lee
Garnet Chan
PRX Quantum, 6 (2025), pp. 020327
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Studies on quantum algorithms for ground-state energy estimation often assume perfect ground-state preparation; however, in reality the initial state will have imperfect overlap with the true ground state. Here, we address that problem in two ways: by faster preparation of matrix-product-state (MPS) approximations and by more efficient filtering of the prepared state to find the ground-state energy. We show how to achieve unitary synthesis with a Toffoli complexity about 7 × lower than that in prior work and use that to derive a more efficient MPS-preparation method. For filtering, we present two different approaches: sampling and binary search. For both, we use the theory of window functions to avoid large phase errors and minimize the complexity. We find that the binary-search approach provides better scaling with the overlap at the cost of a larger constant factor, such that it will be preferred for overlaps less than about 0.003. Finally, we estimate the total resources to perform ground-state energy estimation of Fe-S cluster systems, including the FeMo cofactor by estimating the overlap of different MPS initial states with potential ground states of the FeMo cofactor using an extrapolation procedure. With a modest MPS bond dimension of 4000, our procedure produces an estimate of approximately 0.9 overlap squared with a candidate ground state of the FeMo cofactor, producing a total resource estimate of 7.3e10 Toffoli gates; neglecting the search over candidates and assuming the accuracy of the extrapolation, this validates prior estimates that have used perfect ground-state overlap. This presents an example of a practical path to prepare states of high overlap in a challenging-to-compute chemical system.
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Shadow Hamiltonian Simulation
Rolando Somma
Robbie King
Tom O'Brien
Nature Communications, 16 (2025), pp. 2690
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Simulating quantum dynamics is one of the most important applications of quantum computers. Traditional approaches for quantum simulation involve preparing the full evolved state of the system and then measuring some physical quantity. Here, we present a different and novel approach to quantum simulation that uses a compressed quantum state that we call the "shadow state". The amplitudes of this shadow state are proportional to the time-dependent expectations of a specific set of operators of interest, and it evolves according to its own Schrödinger equation. This evolution can be simulated on a quantum computer efficiently under broad conditions. Applications of this approach to quantum simulation problems include simulating the dynamics of exponentially large systems of free fermions or free bosons, the latter example recovering a recent algorithm for simulating exponentially many classical harmonic oscillators. These simulations are hard for classical methods and also for traditional quantum approaches, as preparing the full states would require exponential resources. Shadow Hamiltonian simulation can also be extended to simulate expectations of more complex operators such as two-time correlators or Green's functions, and to study the evolution of operators themselves in the Heisenberg picture.
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Visualizing Dynamics of Charges and Strings in (2+1)D Lattice Gauge Theories
Tyler Cochran
Bernhard Jobst
Yuri Lensky
Gaurav Gyawali
Norhan Eassa
Melissa Will
Aaron Szasz
Dmitry Abanin
Rajeev Acharya
Laleh Beni
Trond Andersen
Markus Ansmann
Frank Arute
Kunal Arya
Abe Asfaw
Juan Atalaya
Brian Ballard
Alexandre Bourassa
Michael Broughton
David Browne
Brett Buchea
Bob Buckley
Tim Burger
Nicholas Bushnell
Anthony Cabrera
Juan Campero
Hung-Shen Chang
Jimmy Chen
Benjamin Chiaro
Jahan Claes
Agnetta Cleland
Josh Cogan
Roberto Collins
Paul Conner
William Courtney
Alex Crook
Ben Curtin
Sayan Das
Laura De Lorenzo
Agustin Di Paolo
Paul Donohoe
ILYA Drozdov
Andrew Dunsworth
Alec Eickbusch
Aviv Elbag
Mahmoud Elzouka
Vinicius Ferreira
Ebrahim Forati
Austin Fowler
Brooks Foxen
Suhas Ganjam
Robert Gasca
Élie Genois
William Giang
Dar Gilboa
Raja Gosula
Alejo Grajales Dau
Dietrich Graumann
Alex Greene
Steve Habegger
Monica Hansen
Sean Harrington
Paula Heu
Oscar Higgott
Jeremy Hilton
Robert Huang
Ashley Huff
Bill Huggins
Cody Jones
Chaitali Joshi
Pavol Juhas
Hui Kang
Amir Karamlou
Kostyantyn Kechedzhi
Trupti Khaire
Bryce Kobrin
Alexander Korotkov
Fedor Kostritsa
John Mark Kreikebaum
Vlad Kurilovich
Dave Landhuis
Tiano Lange-Dei
Brandon Langley
Kim Ming Lau
Justin Ledford
Kenny Lee
Loick Le Guevel
Wing Li
Alexander Lill
Will Livingston
Daniel Lundahl
Aaron Lunt
Sid Madhuk
Ashley Maloney
Salvatore Mandra
Leigh Martin
Orion Martin
Cameron Maxfield
Seneca Meeks
Anthony Megrant
Reza Molavi
Sebastian Molina
Shirin Montazeri
Ramis Movassagh
Charles Neill
Michael Newman
Murray Ich Nguyen
Chia Ni
Kris Ottosson
Alex Pizzuto
Rebecca Potter
Orion Pritchard
Ganesh Ramachandran
Matt Reagor
David Rhodes
Gabrielle Roberts
Kannan Sankaragomathi
Henry Schurkus
Mike Shearn
Aaron Shorter
Noah Shutty
Vladimir Shvarts
Vlad Sivak
Spencer Small
Clarke Smith
Sofia Springer
George Sterling
Jordan Suchard
Alex Sztein
Doug Thor
Mert Torunbalci
Abeer Vaishnav
Justin Vargas
Sergey Vdovichev
Guifre Vidal
Steven Waltman
Shannon Wang
Brayden Ware
Kristi Wong
Cheng Xing
Jamie Yao
Ping Yeh
Bicheng Ying
Juhwan Yoo
Grayson Young
Yaxing Zhang
Ningfeng Zhu
Yu Chen
Vadim Smelyanskiy
Adam Gammon-Smith
Frank Pollmann
Michael Knap
Nature, 642 (2025), 315–320
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Lattice gauge theories (LGTs) can be used to understand a wide range of phenomena, from elementary particle scattering in high-energy physics to effective descriptions of many-body interactions in materials. Studying dynamical properties of emergent phases can be challenging, as it requires solving many-body problems that are generally beyond perturbative limits. Here we investigate the dynamics of local excitations in a LGT using a two-dimensional lattice of superconducting qubits. We first construct a simple variational circuit that prepares low-energy states that have a large overlap with the ground state; then we create charge excitations with local gates and simulate their quantum dynamics by means of a discretized time evolution. As the electric field coupling constant is increased, our measurements show signatures of transitioning from deconfined to confined dynamics. For confined excitations, the electric field induces a tension in the string connecting them. Our method allows us to experimentally image string dynamics in a (2+1)D LGT, from which we uncover two distinct regimes inside the confining phase: for weak confinement, the string fluctuates strongly in the transverse direction, whereas for strong confinement, transverse fluctuations are effectively frozen. We also demonstrate a resonance condition at which dynamical string breaking is facilitated. Our LGT implementation on a quantum processor presents a new set of techniques for investigating emergent excitations and string dynamics.
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Preview abstract
We present shadow Hamiltonian simulation, a framework for simulating quantum dynamics
using a compressed quantum state that we call the “shadow state”. The amplitudes of this
shadow state are proportional to the expectations of a set of operators of interest. The shadow
state evolves according to its own Schrodinger equation, and under broad conditions can be
simulated on a quantum computer. We analyze a number of applications of this framework to quantum simulation problems. This includes simulating the dynamics of exponentially large systems of free fermions, or exponentially large systems of free bosons, the latter example recovering a recent algorithm for simulating exponentially many classical harmonic oscillators. Shadow Hamiltonian simulation can be extended to simulate expectations of more complex operators such as two-time correlators or Green’s functions, and to study the evolution of operators themselves in the Heisenberg picture
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Expressing and Analyzing Quantum Algorithms with Qualtran
Charles Yuan
Anurudh Peduri
arXiv::2409.04643 (2024)
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Quantum computing's transition from theory to reality has spurred the need for novel software tools to manage the increasing complexity, sophistication, toil, and chance for error of quantum algorithm development. We present Qualtran, an open-source library for representing and analyzing quantum algorithms. Using carefully chosen abstractions and data structures, we can simulate and test algorithms, automatically generate information-rich diagrams, and tabulate resource requirements. Qualtran offers a \emph{standard library} of algorithmic building blocks that are essential for modern cost-minimizing compilations. Its capabilities are showcased through the re-analysis of key algorithms in Hamiltonian simulation, chemistry, and cryptography. The resulting architecture-independent resource counts can be forwarded to our implementation of cost models to estimate physical costs like wall-clock time and number of physical qubits assuming a surface-code architecture. Qualtran provides a foundation for explicit constructions and reproducible analysis, fostering greater collaboration within the quantum algorithm development community. We believe tools like Qualtran will accelerate progress in the field.
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Drug Design on Quantum Computers
Raffaele Santagati
Alán Aspuru-Guzik
Matthias Degroote
Leticia Gonzalez
Elica Kyoseva
Nikolaj Moll
Markus Oppel
Robert Parrish
Michael Streif
Christofer Tautermann
Horst Weiss
Nathan Wiebe
Clemens Utschig-Utschig
Nature Physics (2024)
Preview abstract
The promised industrial applications of quantum computers often rest on their anticipated ability to perform accurate, efficient quantum chemical calculations. Computational drug discovery relies on accurate predictions of how candidate drugs interact with their targets in a cellular environment involving several thousands of atoms at finite temperatures. Although quantum computers are still far from being used as daily tools in the pharmaceutical industry, here we explore the challenges and opportunities of applying quantum computers to drug design. We discuss where these could transform industrial research and identify the substantial further developments needed to reach this goal.
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