General Science
We aim to transform scientific research itself. Many scientific endeavors can benefit from large scale experimentation, data gathering, and machine learning (including deep learning). We aim to accelerate scientific research by applying Google’s computational power and techniques in areas such as drug discovery, biological pathway modeling, microscopy, medical diagnostics, material science, and agriculture. We collaborate closely with world-class research partners to help solve important problems with large scientific or humanitarian benefit.
Recent Publications
An AI system to help scientists write expert-level empirical software
Eser Aygün
Anastasiya Belyaeva
Gheorghe Comanici
Hao Cui
Renee Johnston
Zahra Shamsi
David Smalling
James Thompson
Sarah Martinson
Lai Wei
Yuchen Zhou
Qian-Ze Zhu
Matthew Abraham
Erica Brand
Anna Bulanova
Jeffrey Cardille
Chris Co
Scott Ellsworth
Grace Joseph
Malcolm Kane
Ryan Krueger
Johan Kartiwa
Jackson Cui
Paul Raccuglia
Julie Wang
Kat Chou
James Manyika
Lizzie Dorfman
Shibl Mourad
Nature (2026)
Preview abstract
The cycle of scientific discovery is frequently bottlenecked by the slow, manual creation of software to support computational experiments. To address this, we present Empirical Research Assistance (ERA), an AI system that creates expert-level scientific software whose goal is to maximize a quality metric. The system uses a Large Language Model (LLM) and Tree Search (TS) to systematically improve the quality metric and intelligently navigate the large space of possible solutions. ERA achieves expert-level results when it explores and integrates complex research ideas from external sources. The effectiveness of tree search is demonstrated across a diverse range of tasks. In bioinformatics, ERA discovered 40 novel methods for single-cell data analysis that outperformed the top human-developed methods on a public leaderboard. In epidemiology, ERA generated 14 models that outperformed the CDC ensemble and all other individual models for forecasting COVID-19 hospitalizations. ERA also produced expert-level software for geospatial analysis, neural activity prediction in zebrafish, and numerical solution of integrals, and a novel rule-based construction for time series forecasting. By devising and implementing novel solutions to diverse tasks, ERA represents a significant step towards accelerating scientific progress.
Keywords: Tree Search, Generative AI, Scorable Scientific Tasks, Empirical Software
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MoGen: Detailed Neuronal Morphology Generation via Point Cloud Flow Matching
Franz Rieger
International Conference on Learning Representations (ICLR) (2026)
Preview abstract
Biological neurons come in many shapes. High-fidelity generative modeling of their varied morphologies is challenging yet underexplored in neuroscience, and crucial for the subfield of connectomics. We introduce MoGen (Neuronal Morphology Generation), a flow matching model to generate high-resolution 3D point clouds of mouse cortex axon and dendrite fragments. This is enabled by an adaptation that injects local geometric context into a scalable latent transformer backbone, allowing for the generation of high-fidelity, realistic samples. To assess MoGen's generation quality, we propose a dedicated evaluation suite with interpretable geometric and topological features tailored to neuronal structures that we validate in a user study. MoGen's practical utility is showcased through controllable generation for visualization via smooth interpolation and a direct downstream application: we augment the training set of a shape plausibility classifier from a production connectomics neuron reconstruction pipeline with millions of generated samples, thereby improving classifier accuracy and reducing the number of remaining split and merge errors by 4.4%. We estimate this can reduce manual proofreading labor by over 157 person-years for reconstruction of a full mouse brain.
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Neural general circulation models for modeling precipitation
Stephan Hoyer
Dmitrii Kochkov
Janni Yuval
Ian Langmore
Science Advances (2026)
Preview abstract
Climate models struggle to accurately simulate precipitation, particularly extremes and the diurnal cycle. While hybrid models combining machine learning and physics have emerged with the premise of improving precipitation simulations, none have proven sufficiently skillful or stable enough to outperform existing models in simulating precipitation.
Here, we present the first hybrid model that is trained directly on precipitation observations. The model runs at 2.8 degrees resolution and is built on the differentiable NeuralGCM framework. This model is stable for decadal simulations and demonstrates significant improvements over existing GCMs, ERA5 reanalysis, and a Global Cloud-Resolving Model in simulating precipitation. Our approach yields reduced biases, a more realistic precipitation distribution, improved representation of extremes, and a more accurate diurnal cycle.
Furthermore, it outperforms the ECMWF ensemble for mid-range weather forecasting.
This advance paves the way for more reliable simulations of current climate and for the ability to fully utilize the abundance of existing observations to further improve GCMs.
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Expert evaluation of LLM world models: A high-Tc superconductivity case study
Haoyu Guo
Maria Tikhanovskaya
Paul Raccuglia
Alexey Vlaskin
Chris Co
Scott Ellsworth
Matthew Abraham
Lizzie Dorfman
Peter Armitage
Chunhan Feng
Antoine Georges
Olivier Gingras
Dominik Kiese
Steve Kivelson
Vadim Oganesyan
Brad Ramshaw
Subir Sachdev
Senthil Todadri
John Tranquada
Eun-Ah Kim
Proceedings of the National Academy of Sciences (2026)
Preview abstract
Large Language Models (LLMs) show great promise as a powerful tool for scientific literature exploration. However, their effectiveness in providing scientifically accurate and comprehensive answers to complex questions within specialized domains remains an active area of research. This work evaluates the performance of six different LLM-based systems for answering scientific literature questions, including commercially available closed models and a custom retrieval-augmented generation (RAG) system capable of retrieving images alongside text. We conduct a rigorous expert evaluation of the systems in the domain of high-temperature cuprate superconductors, a research area that involves material science, experimental physics, computation, and theoretical physics. We use an expert-curated database of 1726 scientific papers and a set of 67 expert-formulated questions. The evaluation employs a multi-faceted rubric assessing balanced perspectives, factual comprehensiveness, succinctness, evidentiary support, and image relevance. Our results demonstrate that RAG-based systems, powered by curated data and multimodal retrieval, outperform existing closed models across key metrics, particularly in providing comprehensive and well-supported answers, and in retrieving relevant visual information. This study provides valuable insights into designing and evaluating specialized scientific literature understanding systems, particularly with expert involvement, while also highlighting the importance of rich, domain-specific data in such systems.
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SAC133 - SSAC Comments on Proposed Root KSK Algorithm Rollover
Wes Hardaker
Internet Corporation for Assigned Names and Numbers (ICANN), ICANN Security and Stability Advisory Committee (SSAC) Reports and Advisories (2026), pp. 9
Preview abstract
The SSAC supports the transition from RSA with SHA-256 (Algorithm 8) to ECDSA P-256
with SHA-256 (Algorithm 13) as the cryptographic algorithm for the RootKSK. The root zone
has relied on RSA-based algorithms since DNSSEC signing began in 2010. The algorithm did
not change during the first KSK rollover in 2018 or during the second rollover currently
underway and scheduled to complete in October 2026. Establishing a clear and predictable
process for algorithm transitions is essential to the long-term security of the root zone, and the
SSAC observes that the proposal addresses the Recommendation 23 of the SSR2 Review
accordingly.
The SSAC notes that the proposal builds upon the Root Zone DNSSEC Algorithm Rollover
Study published by ICANN in May 2024, which assessed resolver and authoritative server
support for alternative algorithms, analyzed rollover methodologies, and evaluated operational
risks. The SSAC finds that the proposal implements the study’s recommendations. The SSAC also notes that this proposal is consistent with the SSAC’s prior work on DNSSEC key rollover,
including SAC063, SAC073, SAC102, and SAC108.
The SSAC encourages ICANN to proceed with this rollover. Specific comments on the
proposal’s methodology, timeline, and operational readiness follow
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Towards AI-assisted academic writing
Malcolm Kane
Madeleine Grunde-McLaughlin
Ian Lang
Proceedings of the 1st Workshop on AI and Scientific Discovery: Directions and Opportunities, Association for Computational Linguistics (2025), pp. 31-45
Preview abstract
We present components of an AI-assisted academic writing system including citation recommendation and introduction writing. The system recommends citations by considering the user’s current document context to provide relevant suggestions. It generates introductions in a structured fashion, situating the contributions of the research relative to prior work. We demonstrate the effectiveness of the components through quantitative evaluations. Finally, the paper presents qualitative research exploring how researchers incorporate citations into their writing workflows. Our findings indicate that there is demand for precise AI-assisted writing systems and simple, effective methods for meeting those needs.
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