Machine Intelligence
Google is at the forefront of innovation in Machine Intelligence, with active research exploring virtually all aspects of machine learning, including deep learning and more classical algorithms. Exploring theory as well as application, much of our work on language, speech, translation, visual processing, ranking and prediction relies on Machine Intelligence. In all of those tasks and many others, we gather large volumes of direct or indirect evidence of relationships of interest, applying learning algorithms to understand and generalize.
Machine Intelligence at Google raises deep scientific and engineering challenges, allowing us to contribute to the broader academic research community through technical talks and publications in major conferences and journals. Contrary to much of current theory and practice, the statistics of the data we observe shifts rapidly, the features of interest change as well, and the volume of data often requires enormous computation capacity. When learning systems are placed at the core of interactive services in a fast changing and sometimes adversarial environment, combinations of techniques including deep learning and statistical models need to be combined with ideas from control and game theory.
Recent Publications
The Ontic-Epistemic Distinction: Implications for General Intelligence
Master's Thesis (2026) (to appear)
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The current pursuit of robust machine intelligence is largely predicated on a substrate independent, computational functionalist view of cognition, where sufficiently complex computational processing is expected to eventually yield generalized reasoning. This paper explores the ontological distinctions between these computational frameworks and biological cognition, specifically how these differences impact the capacity for semantic understanding. By analyzing phenomena such as the "reversal curse" where models fail to generalize the symmetry in identity relations (A=B implies B=A), and performance on novel reasoning benchmarks (e.g., ARC-AGI), this paper examines whether current model limitations are transient artifacts of scale or indicative of a distinct architectural category. Integrating Stevan Harnad’s “symbol grounding problem” with Evan Thompson’s biological model of “intrinsic normativity,” I investigate whether robust general intelligence might require sense-making: a process distinct from information processing, whereby an agent’s internal states are causally coupled with its environment via survival or system-wide stakes which grounds symbols in meaning. Current Large Language Models (LLMs) appear to lack this intrinsic normativity, and consequently may operate primarily as epistemic instruments rather than ontic agents. By introducing the concept of “ontic grounding”, this paper presents a potential framework for distinguishing between the simulation of reasoning and true understanding, which could have implications for AI safety and governance.
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An AI system to help scientists write expert-level empirical software
Eser Aygün
Anastasiya Belyaeva
Gheorghe Comanici
Hao Cui
Renee Johnston
Zahra Shamsi
David Smalling
James Thompson
Sarah Martinson
Lai Wei
Yuchen Zhou
Qian-Ze Zhu
Matthew Abraham
Erica Brand
Anna Bulanova
Jeffrey Cardille
Chris Co
Scott Ellsworth
Grace Joseph
Malcolm Kane
Ryan Krueger
Johan Kartiwa
Jackson Cui
Paul Raccuglia
Julie Wang
Kat Chou
James Manyika
Lizzie Dorfman
Shibl Mourad
Nature (2026)
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The cycle of scientific discovery is frequently bottlenecked by the slow, manual creation of software to support computational experiments. To address this, we present Empirical Research Assistance (ERA), an AI system that creates expert-level scientific software whose goal is to maximize a quality metric. The system uses a Large Language Model (LLM) and Tree Search (TS) to systematically improve the quality metric and intelligently navigate the large space of possible solutions. ERA achieves expert-level results when it explores and integrates complex research ideas from external sources. The effectiveness of tree search is demonstrated across a diverse range of tasks. In bioinformatics, ERA discovered 40 novel methods for single-cell data analysis that outperformed the top human-developed methods on a public leaderboard. In epidemiology, ERA generated 14 models that outperformed the CDC ensemble and all other individual models for forecasting COVID-19 hospitalizations. ERA also produced expert-level software for geospatial analysis, neural activity prediction in zebrafish, and numerical solution of integrals, and a novel rule-based construction for time series forecasting. By devising and implementing novel solutions to diverse tasks, ERA represents a significant step towards accelerating scientific progress.
Keywords: Tree Search, Generative AI, Scorable Scientific Tasks, Empirical Software
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Towards Conversational AI for Disease Management
Khaled Saab
David Stutz
Yong Cheng
Kavita Kulkarni
Sara Mahdavi
Joelle Barral
James Manyika
Ryutaro Tanno
Adam Rodman
Nature (2026)
Preview abstract
While large language models (LLMs) have shown promise in diagnostic dialogue, their capabilities for effective management reasoning - including disease progression, therapeutic response, and safe medication prescription - remain under-explored. We advance the previously demonstrated diagnostic capabilities of the Articulate Medical Intelligence Explorer (AMIE) through a new LLM-based agentic system optimised for clinical management and dialogue, incorporating reasoning over the evolution of disease and multiple patient visit encounters, response to therapy, and professional competence in medication prescription. To ground its reasoning in authoritative clinical knowledge, AMIE leverages Gemini's long-context capabilities, combining in-context retrieval with structured reasoning to align its output with relevant and up-to-date clinical practice guidelines and drug formularies. In a randomized, blinded virtual Objective Structured Clinical Examination (OSCE) study, AMIE was compared to 21 primary care physicians (PCPs) across 100 multi-visit case scenarios designed to reflect UK NICE Guidance and BMJ Best Practice guidelines. AMIE was non-inferior to PCPs in management reasoning as assessed by specialist physicians and scored better in both preciseness of treatments and investigations, and in its alignment with and grounding of management plans in clinical guidelines. To benchmark medication reasoning, we developed RxQA, a multiple-choice question benchmark derived from two national drug formularies (US, UK) and validated by board-certified pharmacists. While AMIE and PCPs both benefited from the ability to access external drug information, AMIE outperformed PCPs on higher difficulty questions. While further research would be needed before real-world translation, AMIE's strong performance across evaluations marks a significant step towards conversational AI as a tool in disease management.
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Multi-Agent Design: Optimizing Agents with Better Prompts and Topologies
Han Zhou
Shariq Iqbal
Ivan Vulić
Anna Korhonen
International Conference on Learning Representations (ICLR) (2026)
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Large language models (LLMs), employed as multiple agents that interact and collaborate with each other, have excelled at solving complex tasks. The agents are programmed with {prompts} that declare their functionality, along with the {workflows} that orchestrate interactions within a structured flow. Designing prompts and workflows for multi-agent systems is inherently complex, especially when addressing a new task. It often demands expert-level knowledge and involves significant trial and error. Gaining a deep understanding of the factors that contribute to effective multi-agent systems is essential for automating the entire process. Motivated by this, we first conduct an in-depth analysis of the design spaces for multi-agent systems, focusing on the impact of prompts, scaling the number of agents, and common types of agentic modules. Our findings reveal that top-performing systems often emerge from simpler design spaces, where prompts play a critical role in enhancing agent functionality and enabling more effective scaling. Based on the insights, we propose Multi-Agent System Search (MASS), a multi-stage optimization framework that performs the optimization in a pruned design space, with prompts and an influential subset of modules. We show that MASS-optimized multi-agent systems outperform existing alterntives by a substantial margin. Based on the MASS-found systems, we finally propose design principles behind building effective multi-agent systems.
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Automating AI research differs from general software engineering due to computationally expensive evaluation (e.g., model training) and opaque performance attribution. Current LLM-based agents struggle here, often generating monolithic scripts that ignore execution costs and causal factors. We introduce MARS (Modular Agent with Reflective Search), a framework optimized for autonomous AI research. MARS relies on three pillars: (1) Budget-Aware Planning via cost-constrained Monte Carlo Tree Search (MCTS) to explicitly balance performance with execution expense; (2) Modular Construction, employing a "Design-Decompose-Implement" pipeline to manage complex research repositories; and (3) Comparative Reflective Memory, which addresses credit assignment by analyzing solution differences to distill high-signal insights. MARS achieves state-of-the-art performance among open-source frameworks on MLE-Bench under comparable settings, maintaining competitiveness with the global leaderboard's top methods. Furthermore, the system exhibits qualitative "Aha!" moments, where 63% of all utilized lessons originate from cross-branch transfer, demonstrating that the agent effectively generalizes insights across search paths.
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On-the-Fly OVD Adaptation with FLAME: Few-shot Localization via Active Marginal-Samples Exploration
Yehonathan Refael
Amit Aides
Aviad Barzilai
Vered Silverman
Bolous Jaber
Proceedings of the IEEE/CVF Winter Conference on Applications of Computer Vision (WACV) Workshops (2026), pp. 886-894
Preview abstract
Open-vocabulary object detection (OVD) models offer remarkable flexibility applications by enabling object detection from arbitrary text queries. Still, the zero-shot performance of the pre-trained models is hampered by the inherent semantic ambiguity of natural language, result to low precision, leading to insufficient crucial downstream applications. For instance, in the remote sensing (RS) domain, a query for "ship" can yield varied and contextually irrelevant results. To address this, for real time applications, we propose a novel cascaded architecture that synergizes the broad capabilities of a large, pre-trained OVD model with a lightweight, few-shot classifier. Our approach utilizes the frozen weights of the zero-shot model to generate initial, high-recall object-embedding proposals, which are then refined by a compact classifier trained in real-time on a handful of user-annotated examples. The core of our contribution is an efficient one step active learning strategy for selecting the most informative samples for user annotation. Our method identifies (extremely) small amount of an uncertain candidates near the theoretical decision boundary using density estimation and then applies clustering to ensure a diverse training set. This targeted sampling enables our cascaded system to elevate performance on standard remote sensing benchmarks. Our work thus presents a practical and resource-efficient framework for adapting foundational models to specific user needs, drastically reducing annotation overhead while achieving high accuracy without costly full-model fine-tuning.
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