Avinatan Hassidim
Authored Publications
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Location Not Found: Exposing Implicit Local and Global Biases in Multilingual LLMs
Guy Mor-Lan
Omer Goldman
Matan Eyal
Adi Mayrav Gilady
Sivan Eiger
Reut Tsarfaty
ACL (2026) (to appear)
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Multilingual large language models (LLMs) have minimized the fluency gap between languages. This advancement, however, exposes models to the risk of biased behavior, as knowledge and norms may propagate across languages. In this work, we aim to quantify models' inter- and intra-lingual biases, via their ability to answer locale-ambiguous questions. To this end, we present LocQA, a test set containing 2,156 questions in 12 languages, referring to various locale-dependent facts such as laws, dates, and measurements. The questions do not contain indications of the locales they relate to, other than the querying language itself. LLMs' responses to LocQA locale-ambiguous questions thus reveal models' implicit priors. We used LocQA to evaluate 32 models, and detected two types of structural biases. Inter-lingually, we show a global bias towards answers relevant to the US-locale, even when models are asked in languages other than English. Moreover, we discovered that this global bias is exacerbated in models that underwent instruction tuning, compared to their base counterparts. Intra-lingually, we show that when multiple locales are relevant for the same language, models act as demographic probability engines, prioritizing locales with larger populations. Taken together, insights from LocQA may help in shaping LLMs' desired local behavior, and in quantifying the impact of various training phases on different kinds of biases.
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A prospective clinical feasibility study of a conversational diagnostic AI in an ambulatory primary care clinic
Peter Brodeur
Jacob M. Koshy
Khaled Saab
Ava Homiar
Roma Ruparel
Charles Wu
Ryutaro Tanno
Joseph Xu
Amy Wang
David Stutz
Hannah M. Ferrera
David Barrett
Lindsey Crowley
Jihyeon Lee
Spencer E. Rittner
Selena K. Zhang
Elahe Vedadi
Christine G. Kohn
Kavita Kulkarni
Vinay Kadiyala
Sara Mahdavi
Wendy Du
David Feinbloom
Renee Wong
Petar Sirkovic
Alessio Orlandi
Juro Gottweis
Joelle Barral
Kat Chou
James Manyika
Rob Fields
Jonathan X. Li
Marc L. Cohen
Adam Rodman
arXiv (2026)
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Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Translating these systems into clinical practice requires assessment in real-world workflows with rigorous safety oversight. We report a prospective, single-arm feasibility study of an LLM-based conversational AI, the Articulate Medical Intelligence Explorer (AMIE), conducting clinical history taking and presentation of potential diagnoses for patients to discuss with their provider at urgent care appointments at a leading academic medical center. 100 adult patients completed an AMIE text-chat interaction up to 5 days before their appointment. We sought to assess the conversational safety and quality, patient and clinician experience, and clinical reasoning capabilities compared to primary care providers (PCPs). Human safety supervisors monitored all patient-AMIE interactions in real time and did not need to intervene to stop any consultations based on pre-defined criteria. Patients reported high satisfaction and their attitudes towards AI improved after interacting with AMIE (p < 0.001). PCPs found AMIE's output useful with a positive impact on preparedness. AMIE's differential diagnosis (DDx) included the final diagnosis, per chart review 8 weeks post-encounter, in 90% of cases, with 75% top-3 accuracy. Blinded assessment of AMIE and PCP DDx and management (Mx) plans suggested similar overall DDx and Mx plan quality, without significant differences for DDx (p = 0.6) and appropriateness and safety of Mx (p = 0.1 and 1.0, respectively). PCPs outperformed AMIE in the practicality (p = 0.003) and cost effectiveness (p = 0.004) of Mx. While further research is needed, this study demonstrates the initial feasibility, safety, and user acceptance of conversational AI in a real-world setting, representing crucial steps towards clinical translation.
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Towards conversational artificial intelligence for disease management
Khaled Saab
David Stutz
Yong Cheng
Kavita Kulkarni
Sara Mahdavi
Joelle Barral
James Manyika
Ryutaro Tanno
Adam Rodman
Nature (2026)
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Although large language models have shown promise in diagnostic dialogue, their capabilities for effective management reasoning, including disease progression, therapeutic response and safe medication prescription, have remained underexplored. We have advanced the previously demonstrated diagnostic capabilities of the Articulate Medical Intelligence Explorer (AMIE) using a new large-language-model-based agentic system optimized for multivisit clinical management and dialogue. To ground the reasoning of AMIE in authoritative clinical knowledge, we leveraged the long-context capabilities of Gemini, combining in-context retrieval with structured reasoning to align its output with up-to-date clinical practice guidelines and drug formularies. In a randomized, blinded virtual Objective Structured Clinical Examination study, AMIE was compared to 21 primary care physicians (PCPs) across 100 multivisit case scenarios designed to reflect the guidance of the UK National Institute for Health and Care Excellence and BMJ Best Practice guidelines. AMIE was non-inferior to PCPs in management reasoning, as assessed by specialists, and scored better both with respect to preciseness of treatment and investigation, and in terms of its alignment with and grounding in clinical guidelines. To benchmark medication reasoning, we developed RxQA, a multiple-choice question benchmark that was derived from two national drug formularies (from the USA and UK) and validated by board-certified pharmacists. Although AMIE and PCPs both benefited from the ability to access external drug information, AMIE outperformed PCPs on higher-difficulty questions. Although further research will be needed before real-world translation of AMIE, its strong performance across evaluations marks a significant step towards use of conversational artificial intelligence as a tool in disease management.
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Towards expert-level medical AI for real-time video consultations
Mahvish Nagda
Jihyeon Lee
Matthew Thompson
CJ Park
Tim Strother
Roma Ruparel
Teya Bergamaschi
Suhana Bedi
Meet Shah
Pavel Dubov
Toshiyuki Fukuzawa
Sam Schmidgall
Craig Schiff
Joseph Xu
Aliya Rysbek
Yana Lunts
Jan Freyberg
Rebecca Hemenway
David Racz
Carey Radebaugh
Joelle Barral
Kavi Goel
Kat Chou
James Manyika
Gregory Wayne
Yun Liu
Ethan Goh
Christina Chen
Ryutaro Tanno
arXiv (2026)
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Audio-visual interaction is the standard for patient-physician consultations, enabling natural communication and effective assessment of illness through non-verbal cues. While text-based AI has shown promise, it discards essential perceptual dimensions and limits patients who cannot articulate symptoms in writing. Early efforts to extend medical AI to audio-visual interaction have demonstrated feasibility, but not reached clinician-level performance. Here, we provide the first demonstration of expert-level AI in real-time clinical video consultations using AMIE (Articulate Medical Intelligence Explorer) in a video configuration. AMIE (Video) is a Gemini-based multi-agent system integrating low-latency dialogue, clinical reasoning, and real-time audio-visual perception. To guide development, we established a taxonomy and automated evaluations for clinical audio-visual cues in telehealth settings. In a randomized Objective Structured Clinical Examination (OSCE) study with 30 primary care physicians (PCPs), 15 patient actors and 100 clinical scenarios, we compared AMIE (Video), its text-only counterpart AMIE (Text), and PCPs consulting via video. Clinical evaluators rated AMIE (Video) on par or better than PCPs in history-taking, diagnosis, management, and physical observation and examination. Patient actors preferred AMIE's approach to assessing and explaining conditions, while PCPs were preferred for rapport and partnership building. In modality ablation, patient actors preferred AMIE (Video)'s interface over text chat for communicative effectiveness, convenience, and feeling understood. Limitations remain in fine anatomical precision, subtle affective nuances, and high-frequency movements. While further research is needed before real-world translation, these results mark an important milestone toward AI systems capable of augmenting care across the sensory complexity of clinical practice.
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Prospective evidence for conversational medical AI is hard, but non-negotiable
Adam Rodman
Ami Parekh
Ethan Goh
Christina Chen
Joelle Barral
Nature Medicine (2026)
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Trust in clinical artificial intelligence (AI) cannot be benchmarked into existence. It must be earned through rigorous prospective studies in real-world clinical settings, where the hardest lessons often concern the humans and systems around the AI, not the technology itself.
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Day-of-the-week Awareness in Time of Day Breakpoints for Traffic Light Plans
Ori Rottenstreich
Eliav Buchnik
Shai Ferster
Tom Kalvari
Ron Tsibulsky
Danny Veikherman
Jack Haddad
2025
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Time-of-day breakpoints (TODs) refer to the times over the day in which the plan of a traffic light is changed. Traditionally, TODs are selected jointly for all weekdays (Monday-Friday), typically with additional TODs dedicated to weekends. In this paper, we present an alternative approach motivated by traffic characteristics that can differ among the weekdays Monday-Friday and consider TODs which are day-of-the-week aware. The traffic-aware approach studies similarities among days and computes TODs that can be shared among days with similar characteristics but can also have other forms for weekdays with unique characteristics. Based on traffic properties derived from anonymized trajectories, we apply the new methodology to compute time-of-day breakpoints that are day-of-the-week aware in the city of Rio de Janeiro, Brazil and estimate the impact of the new methodology.
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Study of Arterials in the City of Rio de Janeiro for Traffic Coordination
Ori Rottenstreich
Eliav Buchnik
Danny Veikherman
Dan Karliner
Tom Kalvari
Shai Ferster
Ron Tsibulsky
Jack Haddad
2025
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Urban traffic congestion is a growing challenge, and optimizing signal timing strategies is crucial for improving traffic flow and reducing emissions. The coordination of signalized intersections improves both traffic operations and environmental aspects. Coordination is particularly important along arterials, sequences of signalized intersections that serve as the primary routes and carry a high volume of traffic. In this paper we analyze real data from the city of Rio de Janeiro to study properties of arterials. We refer to their length, the distance between intersections and to the properties of the traffic light plans such as cycle time. We then study their in practice level of coordination in terms of number of stops and their common locations along the arterials. We dive into particular arterials and provide insights that can be useful for efficient design of arterials in additional cities. Based on the analysis, we show how simple traffic properties can indicate the potential upon coordinating two adjacent intersections as part of an arterial in improving traffic performance.
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Earth AI: Unlocking Geospatial Insights with Foundation Models and Cross-Modal Reasoning
Aaron Bell
Aviad Barzilai
Roy Lee
Gia Jung
Charles Elliott
Adam Boulanger
Amr Helmy
Jacob Bien
Ruth Alcantara
Nadav Sherman
Hassler Thurston
Yotam Gigi
Bolous Jaber
Vered Silverman
Luke Barrington
Tim Thelin
Elad Aharoni
Kartik Hegde
Yuval Carny
Shravya Shetty
Yehonathan Refael
Stone Jiang
David Schottlander
Juliet Rothenberg
Luc Houriez
Yochai Blau
Joydeep Paul
Yang Chen
Yael Maguire
Aviv Slobodkin
Shlomi Pasternak
Alex Ottenwess
Jamie McPike
Per Bjornsson
Natalie Williams
Reuven Sayag
Thomas Turnbull
Ali Ahmadalipour
David Andre
Amit Aides
Ean Phing VanLee
Niv Efron
Monica Bharel
arXiv (preprint 2025), arXiv, arXiv:2510.18318
https://doi.org/10.48550/arXiv.2510.18318
(2025)
Preview abstract
Geospatial data offers immense potential for understanding our planet. However, the sheer volume and diversity of this data along with its varied resolutions, timescales, and sparsity pose significant challenges for thorough analysis and interpretation. The emergence of Foundation Models (FMs) and Large Language Models (LLMs) offers an unprecedented opportunity to tackle some of this complexity, unlocking novel and profound insights into our planet.
This paper introduces a comprehensive approach to developing Earth AI solutions, built upon foundation models across three key domains—Planet-scale Imagery, Population, and Environment—and an intelligent Gemini-powered reasoning engine. We present rigorous benchmarks showcasing the power and novel capabilities of our foundation models and validate that they provide complementary value to improve geospatial inference. We show that the synergy between these models unlocks superior predictive capabilities. To handle complex, multi-step queries, we developed a Gemini-powered agent that jointly reasons over our multiple foundation models along with large geospatial data sources and tools to unlock novel geospatial insights. On a new benchmark of real-world crisis scenarios, our agent demonstrates the ability to deliver critical and timely insights, effectively bridging the gap between raw geospatial data and actionable understanding.
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An Empirical Study of Time of Day Breakpoints in Traffic Light Plans
Eliav Buchnik
Tom Kalvari
Jack Haddad
Dan Karliner
Danny Veikherman
Shai Ferster
Ori Rottenstreich
2025
Preview abstract
Fixed time strategy is a common approach in signal traffic control in which signal plans are simple and periodic, enjoying easy implementation without detection mechanisms. A traffic light is associated with several daily plans, each applied to several consecutive hours. Time-of-day breakpoints (TODs) refer to the times over the day in which the plan is changed. TODs are often selected based on traffic, aiming to divide the day into groups of consecutive hours with similar traffic characteristics within each group of hours. We present a methodology to study time-of-day breakpoints in practice. We use this methodology to estimate and analyze time-of-day breakpoints in the city of Rio de Janeiro, Brazil based on traffic properties derived from traffic trajectories. Our study examines over 900 of the city intersections. We refer to properties such as the number of daily plans and the times by which plans start. We also provide traffic-aware insights on the potential improvement in the selection of TODs and identify key intersections where adjusting TODs could reduce average delay times. We identify potential improvements in over 8% of the examined intersections. These findings provide valuable insights for traffic engineers seeking to optimize signal timing.
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A unified acoustic-to-speech-to-language embedding space captures the neural basis of natural language processing in everyday conversations
Uri Hasson
Samuel A. Nastase
Harshvardhan Gazula
Aditi Rao
Tom Sheffer
Werner Doyle
Orrin Devinsky
aditi singh
Adeen Flinker
Patricia Dugan
Bobbi Aubrey
Sasha Devore
Daniel Friedman
Leonard Niekerken
Catherine Kim
Haocheng Wang
Zaid Zada
Gina Choe
Nature Human Behaviour (2025)
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This study introduces a unified computational framework connecting acoustic, speech and word-level linguistic structures to study the neural basis of everyday conversations in the human brain. We used electrocorticography to record neural signals across 100 h of speech production and comprehension as participants engaged in open-ended real-life conversations. We extracted low-level acoustic, mid-level speech and contextual word embeddings from a multimodal speech-to-text model (Whisper). We developed encoding models that linearly map these embeddings onto brain activity during speech production and comprehension. Remarkably, this model accurately predicts neural activity at each level of the language processing hierarchy across hours of new conversations not used in training the model. The internal processing hierarchy in the model is aligned with the cortical hierarchy for speech and language processing, where sensory and motor regions better align with the model’s speech embeddings, and higher-level language areas better align with the model’s language embeddings. The Whisper model captures the temporal sequence of language-to-speech encoding before word articulation (speech production) and speech-to-language encoding post articulation (speech comprehension). The embeddings learned by this model outperform symbolic models in capturing neural activity supporting natural speech and language. These findings support a paradigm shift towards unified computational models that capture the entire processing hierarchy for speech comprehension and production in real-world conversations.
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