Avinatan Hassidim
Authored Publications
Sort By
Towards expert-level medical AI for real-time video consultations
Mahvish Nagda
Jihyeon Lee
Matthew Thompson
CJ Park
Tim Strother
Roma Ruparel
Teya Bergamaschi
Suhana Bedi
Meet Shah
Pavel Dubov
Toshiyuki Fukuzawa
Sam Schmidgall
Craig Schiff
Joseph Xu
Aliya Rysbek
Yana Lunts
Jan Freyberg
Rebecca Hemenway
David Racz
Carey Radebaugh
Joelle Barral
Kavi Goel
Kat Chou
James Manyika
Gregory Wayne
Yun Liu
Ethan Goh
Christina Chen
Ryutaro Tanno
arXiv (2026)
Preview abstract
Audio-visual interaction is the standard for patient-physician consultations, enabling natural communication and effective assessment of illness through non-verbal cues. While text-based AI has shown promise, it discards essential perceptual dimensions and limits patients who cannot articulate symptoms in writing. Early efforts to extend medical AI to audio-visual interaction have demonstrated feasibility, but not reached clinician-level performance. Here, we provide the first demonstration of expert-level AI in real-time clinical video consultations using AMIE (Articulate Medical Intelligence Explorer) in a video configuration. AMIE (Video) is a Gemini-based multi-agent system integrating low-latency dialogue, clinical reasoning, and real-time audio-visual perception. To guide development, we established a taxonomy and automated evaluations for clinical audio-visual cues in telehealth settings. In a randomized Objective Structured Clinical Examination (OSCE) study with 30 primary care physicians (PCPs), 15 patient actors and 100 clinical scenarios, we compared AMIE (Video), its text-only counterpart AMIE (Text), and PCPs consulting via video. Clinical evaluators rated AMIE (Video) on par or better than PCPs in history-taking, diagnosis, management, and physical observation and examination. Patient actors preferred AMIE's approach to assessing and explaining conditions, while PCPs were preferred for rapport and partnership building. In modality ablation, patient actors preferred AMIE (Video)'s interface over text chat for communicative effectiveness, convenience, and feeling understood. Limitations remain in fine anatomical precision, subtle affective nuances, and high-frequency movements. While further research is needed before real-world translation, these results mark an important milestone toward AI systems capable of augmenting care across the sensory complexity of clinical practice.
View details
A prospective clinical feasibility study of a conversational diagnostic AI in an ambulatory primary care clinic
Peter Brodeur
Jacob M. Koshy
Khaled Saab
Ava Homiar
Roma Ruparel
Charles Wu
Ryutaro Tanno
Joseph Xu
Amy Wang
David Stutz
Hannah M. Ferrera
David Barrett
Lindsey Crowley
Jihyeon Lee
Spencer E. Rittner
Selena K. Zhang
Elahe Vedadi
Christine G. Kohn
Kavita Kulkarni
Vinay Kadiyala
Sara Mahdavi
Wendy Du
David Feinbloom
Renee Wong
Petar Sirkovic
Alessio Orlandi
Juro Gottweis
Joelle Barral
Kat Chou
James Manyika
Rob Fields
Jonathan X. Li
Marc L. Cohen
Adam Rodman
arXiv (2026)
Preview abstract
Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Translating these systems into clinical practice requires assessment in real-world workflows with rigorous safety oversight. We report a prospective, single-arm feasibility study of an LLM-based conversational AI, the Articulate Medical Intelligence Explorer (AMIE), conducting clinical history taking and presentation of potential diagnoses for patients to discuss with their provider at urgent care appointments at a leading academic medical center. 100 adult patients completed an AMIE text-chat interaction up to 5 days before their appointment. We sought to assess the conversational safety and quality, patient and clinician experience, and clinical reasoning capabilities compared to primary care providers (PCPs). Human safety supervisors monitored all patient-AMIE interactions in real time and did not need to intervene to stop any consultations based on pre-defined criteria. Patients reported high satisfaction and their attitudes towards AI improved after interacting with AMIE (p < 0.001). PCPs found AMIE's output useful with a positive impact on preparedness. AMIE's differential diagnosis (DDx) included the final diagnosis, per chart review 8 weeks post-encounter, in 90% of cases, with 75% top-3 accuracy. Blinded assessment of AMIE and PCP DDx and management (Mx) plans suggested similar overall DDx and Mx plan quality, without significant differences for DDx (p = 0.6) and appropriateness and safety of Mx (p = 0.1 and 1.0, respectively). PCPs outperformed AMIE in the practicality (p = 0.003) and cost effectiveness (p = 0.004) of Mx. While further research is needed, this study demonstrates the initial feasibility, safety, and user acceptance of conversational AI in a real-world setting, representing crucial steps towards clinical translation.
View details
Location Not Found: Exposing Implicit Local and Global Biases in Multilingual LLMs
Guy Mor-Lan
Omer Goldman
Matan Eyal
Adi Mayrav Gilady
Sivan Eiger
Reut Tsarfaty
ACL (2026) (to appear)
Preview abstract
Multilingual large language models (LLMs) have minimized the fluency gap between languages. This advancement, however, exposes models to the risk of biased behavior, as knowledge and norms may propagate across languages. In this work, we aim to quantify models' inter- and intra-lingual biases, via their ability to answer locale-ambiguous questions. To this end, we present LocQA, a test set containing 2,156 questions in 12 languages, referring to various locale-dependent facts such as laws, dates, and measurements. The questions do not contain indications of the locales they relate to, other than the querying language itself. LLMs' responses to LocQA locale-ambiguous questions thus reveal models' implicit priors. We used LocQA to evaluate 32 models, and detected two types of structural biases. Inter-lingually, we show a global bias towards answers relevant to the US-locale, even when models are asked in languages other than English. Moreover, we discovered that this global bias is exacerbated in models that underwent instruction tuning, compared to their base counterparts. Intra-lingually, we show that when multiple locales are relevant for the same language, models act as demographic probability engines, prioritizing locales with larger populations. Taken together, insights from LocQA may help in shaping LLMs' desired local behavior, and in quantifying the impact of various training phases on different kinds of biases.
View details
Prospective evidence for conversational medical AI is hard, but non-negotiable
Adam Rodman
Ami Parekh
Ethan Goh
Christina Chen
Joelle Barral
Nature Medicine (2026)
Preview abstract
Trust in clinical artificial intelligence (AI) cannot be benchmarked into existence. It must be earned through rigorous prospective studies in real-world clinical settings, where the hardest lessons often concern the humans and systems around the AI, not the technology itself.
View details
Towards conversational artificial intelligence for disease management
Khaled Saab
David Stutz
Yong Cheng
Kavita Kulkarni
Sara Mahdavi
Joelle Barral
James Manyika
Ryutaro Tanno
Adam Rodman
Nature (2026)
Preview abstract
Although large language models have shown promise in diagnostic dialogue, their capabilities for effective management reasoning, including disease progression, therapeutic response and safe medication prescription, have remained underexplored. We have advanced the previously demonstrated diagnostic capabilities of the Articulate Medical Intelligence Explorer (AMIE) using a new large-language-model-based agentic system optimized for multivisit clinical management and dialogue. To ground the reasoning of AMIE in authoritative clinical knowledge, we leveraged the long-context capabilities of Gemini, combining in-context retrieval with structured reasoning to align its output with up-to-date clinical practice guidelines and drug formularies. In a randomized, blinded virtual Objective Structured Clinical Examination study, AMIE was compared to 21 primary care physicians (PCPs) across 100 multivisit case scenarios designed to reflect the guidance of the UK National Institute for Health and Care Excellence and BMJ Best Practice guidelines. AMIE was non-inferior to PCPs in management reasoning, as assessed by specialists, and scored better both with respect to preciseness of treatment and investigation, and in terms of its alignment with and grounding in clinical guidelines. To benchmark medication reasoning, we developed RxQA, a multiple-choice question benchmark that was derived from two national drug formularies (from the USA and UK) and validated by board-certified pharmacists. Although AMIE and PCPs both benefited from the ability to access external drug information, AMIE outperformed PCPs on higher-difficulty questions. Although further research will be needed before real-world translation of AMIE, its strong performance across evaluations marks a significant step towards use of conversational artificial intelligence as a tool in disease management.
View details
Study of Arterials in the City of Rio de Janeiro for Traffic Coordination
Ori Rottenstreich
Eliav Buchnik
Danny Veikherman
Dan Karliner
Tom Kalvari
Shai Ferster
Ron Tsibulsky
Jack Haddad
2025
Preview abstract
Urban traffic congestion is a growing challenge, and optimizing signal timing strategies is crucial for improving traffic flow and reducing emissions. The coordination of signalized intersections improves both traffic operations and environmental aspects. Coordination is particularly important along arterials, sequences of signalized intersections that serve as the primary routes and carry a high volume of traffic. In this paper we analyze real data from the city of Rio de Janeiro to study properties of arterials. We refer to their length, the distance between intersections and to the properties of the traffic light plans such as cycle time. We then study their in practice level of coordination in terms of number of stops and their common locations along the arterials. We dive into particular arterials and provide insights that can be useful for efficient design of arterials in additional cities. Based on the analysis, we show how simple traffic properties can indicate the potential upon coordinating two adjacent intersections as part of an arterial in improving traffic performance.
View details
Generative AI for medical education: Insights from a case study with medical students and an AI tutor for clinical reasoning
Amy Wang
Roma Ruparel
Paul Jhun
Julie Anne Seguin
Patricia Strachan
Renee Wong
CHI (2025) (to appear)
Preview abstract
Generative Artificial Intelligence (AI), particularly Large Language Models (LLMs), have demonstrated significant potential in clinical reasoning skills such as history-taking and differential diagnosis generation—critical aspects of medical education. This work explores how LLMs can augment medical curricula through interactive learning. We conducted a participatory design process with medical students, residents and medical education experts to co-create an AI-powered tutor prototype for clinical reasoning. As part of the co-design process, we conducted a qualitative user study, investigating learning needs and practices via interviews, and conducting concept evaluations through interactions with the prototype. Findings highlight the challenges learners face in transitioning from theoretical knowledge to practical application, and how an AI tutor can provide personalized practice and feedback. We conclude with design considerations, emphasizing the importance of context-specific knowledge and emulating positive preceptor traits, to guide the development of AI tools for medical education.
View details
LLM-based Lossless Text Simplification and its Effect on User Comprehension and Mental Load
Theo Guidroz
Diego Ardila
Jimmy Li
Adam Mansour
Paul Jhun
Nina Gonzalez
Xiang Ji
Mike Sanchez
Sujay Kakarmath
Miguel Ángel Garrido
Faruk Ahmed
Divyansh Choudhary
Jay Hartford
Georgina Xu
Henry Serrano
Yifan Wang
Jeff Shaffer
Eric (Yifan) Cao
Sho Fujiwara
Peggy Bui
arXiv (2025)
Preview abstract
Information on the web, such as scientific publications and Wikipedia, often surpasses users' reading level. To help address this, we used a self-refinement approach to develop a LLM capability for minimally lossy text simplification. To validate our approach, we conducted a randomized study involving 4563 participants and 31 texts spanning 6 broad subject areas: PubMed (biomedical scientific articles), biology, law, finance, literature/philosophy, and aerospace/computer science. Participants were randomized to viewing original or simplified texts in a subject area, and answered multiple-choice questions (MCQs) that tested their comprehension of the text. The participants were also asked to provide qualitative feedback such as task difficulty. Our results indicate that participants who read the simplified text answered more MCQs correctly than their counterparts who read the original text (3.9% absolute increase, p<0.05). This gain was most striking with PubMed (14.6%), while more moderate gains were observed for finance (5.5%), aerospace/computer science (3.8%) domains, and legal (3.5%). Notably, the results were robust to whether participants could refer back to the text while answering MCQs. The absolute accuracy decreased by up to ~9% for both original and simplified setups where participants could not refer back to the text, but the ~4% overall improvement persisted. Finally, participants' self-reported perceived ease based on a simplified NASA Task Load Index was greater for those who read the simplified text (absolute change on a 5-point scale 0.33, p<0.05). This randomized study, involving an order of magnitude more participants than prior works, demonstrates the potential of LLMs to make complex information easier to understand. Our work aims to enable a broader audience to better learn and make use of expert knowledge available on the web, improving information accessibility.
View details
Fine-grained Measurement of Vehicle Delay Fairness
Eliav Buchnik
Tom Kalvari
Jack Haddad
Dan Karliner
Danny Veikherman
Ron Tsibulsky
Shai Ferster
Ori Rottenstreich
2025
Preview abstract
Optimizing signal timing in traffic lights helps to improve traffic flow and reduce emissions through reducing delays. At intersections, vehicles from different movements observe different delays impacted by the traffic light plan. This paper analyzes delay fairness among various vehicles at intersections. We refer to three cities: Rio de Janeiro, Hamburg and Seattle with a total number of over 5100 intersections. We present an intuitive methodology to compute delay fairness based on Gini index, a common fairness measure in economics. We evaluate the fairness based on real traffic data and provide insights on the relationship of fairness with day hours and traffic demand. We also examine real changes in traffic light plans that occurred in practice to check whether improving delay is often aligned with increasing fairness.
View details
Fine-grained Measurement of Vehicle Delay Fairness
Eliav Buchnik
Tom Kalvari
Jack Haddad
Dan Karliner
Danny Veikherman
Ron Tsibulsky
Shai Ferster
Ori Rottenstreich
2025
Preview abstract
Optimizing signal timing in traffic lights helps to improve traffic flow and reduce emissions through reducing delays. At intersections, vehicles from different movements observe different delays impacted by the traffic light plan. This paper analyzes delay fairness among various vehicles at intersections. We refer to three cities: Rio de Janeiro, Hamburg and Seattle with a total number of over 5100 intersections. We present an intuitive methodology to compute delay fairness based on Gini index, a common fairness measure in economics. We evaluate the fairness based on real traffic data and provide insights on the relationship of fairness with day hours and traffic demand. We also examine real changes in traffic light plans that occurred in practice to check whether improving delay is often aligned with increasing fairness.
View details
